- Original Article
- Gastroenterology
- Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients
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Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi
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Clin Exp Pediatr. 2019;62(10):400-404. Published online July 3, 2019
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Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.
Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement.
Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with... |
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- Clinical significance of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 and 2 in Kawasaki disease
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Ki Wook Yun, Sin Weon Sin, Jung Ju Lee, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo, Mi-Kyung Lee
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Clin Exp Pediatr. 2010;53(4):510-518. Published online April 15, 2010
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Purpose : Kawasaki disease (KD) is a systemic vasculitis, a leading cause of pediatric acquired heart disease. Histopathological findings of coronary artery lesion (CAL) in KD indicate destruction of the coronary artery wall with diffuse vasculitis. Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) might play central roles in this process. Special attention to MMP-9 has recently been emerging.... |
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- Epidemiologic and clinical features in children with acute lower respiratory
tract infection caused by human metapneumovirus in 2006-2007
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Gwi Ok Park, Ji Hyun Kim, Jae Hee Lee, Jung Ju Lee, Sin Weon Yun, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo,, Mi Kyung Lee, Soo Ahn Chae
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Clin Exp Pediatr. 2009;52(3):330-338. Published online March 15, 2009
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Purpose : The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient,... |
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- Case Report
- A case of herpes zoster in a 4-month-old infant
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Ji Hyun Kim, Jung Ju Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo
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Clin Exp Pediatr. 2008;51(12):1368-1371. Published online December 15, 2008
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Herpes zoster in infancy is very rare but can be developed following intrauterine or postnatal exposure to varicella zoster virus. We report a case of herpes zoster in a 4-month-old male infant. He had no prior history of primary varicella or varicella vaccination. His mother had no history of varicella infection and no contact history with varicella during pregnancy. He... |
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- Original Article
- Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
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Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
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Clin Exp Pediatr. 2007;50(10):995-1004. Published online October 15, 2007
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Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease.
Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed... |
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- Effects of electromagnetic stimulation on neurogenesis and neuronal proliferation in rat hippocampal slice culture
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Deok-Soo Kim, Eung Sang Choi, Soo Ahn Chae
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Clin Exp Pediatr. 2006;49(5):558-564. Published online May 15, 2006
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Purpose : Transcranial electromagnetic stimulation(TMS) is a noninvasive method which stimulates the central nervous system through pulsed magnetic fields without direct effect on the neurons. Although the neurobiologic mechanisms of magnetic stimulation are unknown, the effects on the brain are variable according to the diverse stimulation protocols. This study aims to observe the effect of the magnetic stimulation with two... |
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- Therapeutic Effect of Anti-Rotavirus Chicken Egg Yolk Immunoglobulin(IgY) on Diarrhea by Infection of Rotavirus
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In Seok Lim, Ho Seok Lee, Wonyong Kim, Eung Sang Choi, Dong Hyuk Jung, Hoo Kil Jung, Sung Seob Yun, Ho Nam Chun
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Clin Exp Pediatr. 2005;48(12):1354-1361. Published online December 15, 2005
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Purpose : Rotavirus is an enteric pathogen that affects millions of children globally each year. But no specific therapy is available for the management of rotavirus diarrhea. Due to the clear need to define improved modality for treatment of rotavirus diarrhea, we evaluated the efficacy of anti- rotavirus IgY in the treatment of infants and children with gastroenteritis.
Methods : First,... |
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- Case Report
- A Case of Teratocarcinoma with Central Diabetes Insipidus
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Jong Hoon Kim, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo
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Clin Exp Pediatr. 2004;47(4):453-457. Published online April 15, 2004
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Central diabetes insipidus is a rare disorder that can result as a consequence of diverse etiologies, including malformations, autoimmune, infiltrative(e.g. neoplastic or histiocytosis) or traumatic processes, as well as mutations in the gene encoding arginine vasopressin. Idiopathic central diabetes insipidus is a diagnosis of exclusion, one that has been made less frequently through the decades. Idiopathic central diabetes insipidus in... |
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- Factors Predictive of Response to Interferon-α Therapy in
Children with Chronic Hepatitis B
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Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
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Clin Exp Pediatr. 2000;43(4):514-519. Published online April 15, 2000
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Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB.
Methods : The basal... |
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- Apoptosis, P53, bax and Bcl-2 Protein Expressions in Neonatal rat Hippocampus by Kainic Acid-induced Seizure
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Shin Weon Yun, Soo Ahn Chae, Eung sang Choi, Byoung Hoon Yoo
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Clin Exp Pediatr. 2000;43(1):85-96. Published online January 15, 2000
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Purpose : Apoptosis is a process of active cell death which has been suggested to be part of
hippocampal cell loss caused by kainic acid(KA). Immature rats showed higher susceptibility and
mortality to KA but did not develop recurrent seizure, long term behavioral or neuropathologic
changes. We investigated whether this was due to age-dependent resistance, and elucidated the
molecular mechanics which mediate P53-induced apoptosis,... |
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- Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
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Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
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Clin Exp Pediatr. 1999;42(5):672-678. Published online May 15, 1999
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Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity.
Methods : We measured the serum concentrations of ECP... |
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- A case of malignant atrophic papulosis (Degos' disease).
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Sung Ku Lee, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo, Gae Yong Song
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Clin Exp Pediatr. 1991;34(12):1724-1729. Published online December 31, 1991
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Malignant atrophic papulosis (Degos’ disease) is characterized by porcelain-white skin lesions. It
has unknown etiology and bad prognosis. Death usually occurs from multiple intestinal perforations
weeks to years after onset.
We experienced a case of Degos’ disease in a 12-year-old male patient who had porcelain white
papules on face, trunk and extremities. Histopathologic studies showed broad epidermal necrobiosis
with thrombotic arteriolar occlusion.
A brief review of... |
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- A Study of Serum Transaminase Level and It's Correlation with Dehydration in Children with HRV Gastroenteritis.
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Tae Joon Park, Eung Sang Choi
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Clin Exp Pediatr. 1990;33(12):1662-1669. Published online December 31, 1990
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The study was taken to study the serum transaminase level and it’s correlation with dehydration
in Human Rotavirus gastroenteritis.
129 children, who admitted to the Department of Pediatrics in Chung-Ang University Hospital from
January 1987 to December 1989 with chief complaints of fever, vomiting, and watery diarrhea were
included in this studies. The stool specimen on admission was tested for Rotavirus Ag by ELISA
method.... |
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- Case Report
- A Case of Thanatophoric Dwarfism.
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Hae Seong Lee, Wha Young Chung, Eung Sang Choi, Tae Sub Shim
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Clin Exp Pediatr. 1983;26(9):922-927. Published online September 30, 1983
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Thanatophoric dwarfism is a lethal congenital chondrodystrophy characterized by diminished
vertebral body height, a narrow thorax, and micromelia.
This report presents the clinical, radiographic and autopsy findings of an experienced case
of thanatophoric dwarfism detected prenatally by radiologic examination and discusses the
differentiation of this disorder from other forms of congenital short limbed dwarfism.
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- Aneurysm of the Main Pulmonary Artery-Report of a case and review of the literature.
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Eue Cho Yang, Eung Sang Choi, Yong Soo Yoon, Chang Yee Hong, Joon Ryang Roh, Kyung Mo Yeon
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Clin Exp Pediatr. 1982;25(2):162-167. Published online February 28, 1982
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Pulmonary artery aneurysms are extremely rate and are seldom diagnosed during life. In true aneurysms, dilatation tends to be confined to the main trunk of the artery and degenerative changes in the wall are found. In 1971, Williams et al reported the first successful excision and replacement of the main pulmonary artery, including the bifurcation, with a dacron graft. Since... |
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- Two Cases of Pulmonary Sequestrations.
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Woong Heum Kim, Ji Suck Chang, Soon Woong Kang, Eung Sang Choi, Yong Su Yoon, Chong Gu Yoon, Kwang Wook Ko
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Clin Exp Pediatr. 1982;25(10):1058-1062. Published online October 31, 1982
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We have experienced two cases of pulmonary sequestrations. The first case, 49/I2 year old
girl, was admitted for ths evaluation of recurrent pneumonia of left lower lung. The diagnosis
of pulmonary sequestration was made by aortography, which demonstrate tortuous aberrant
artery suppling the left posterobasal segment from the intrathoracic descending aorta at Tlo
유卜 level, and the sequestration was successfully resected by lobectomy. The... |
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- Original Article
- Clinical Obseervation for Hematologic Disorders in Children.
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Eung Sang Choi, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Chang Yoo Hong
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Clin Exp Pediatr. 1981;24(3):235-244. Published online March 15, 1981
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Nine hundred and twenty-three cases of hematologic disorders in children who were admi-tted to department of pediatrics, SNUH, from 1955 to Oct. 1980 were analysed. The patients consisted of 624 males and 299 females. The results were as follows; 1.Mean annual percentage of hematologic patients among total admitted patients was 6.8%. 2.The peak age incidence of various hematologic disorders was... |
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- Total Serum bilirubin concentration of Physiologic Jaundice of Healthy, full-term Infants.
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Eung Sang Choi, Chang Hyo Lee, Chong Ku Yun
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Clin Exp Pediatr. 1980;23(2):111-117. Published online February 15, 1980
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The bilirubin formed in utero by the fetus can cross the placena and be excreted by the maternal liver. After birth, however, the infant must excrete its own bilirubin and hepatic clearance is not sufficient to prevent its accumulation during first week of life This transition has been physiologic jaundice and defined as an elevation of serum bilirubin that does... |
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- The Time of the First Stool and Urine by the Low Birth Weight, Premature Infant.
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Chong Ku Yoon, Eung Sang Choi
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Clin Exp Pediatr. 1979;22(11):947-955. Published online November 15, 1979
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The times of passage of the first stool and urine in the newborn infant are important because delayed micturition may indicate urinary tract pathology and failure to pass meconium may be an early sign of intestinal obsturuction. Times of first void and first stool in 180 consecutive low birth weight, premature infant born at Seoul National University Hospital during 44... |
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